منابع مشابه
Kappa-chain deficiency.
A decreased concentration of immunogesting that the synthesis of molecules globulin molecules of one light chain bearing K-chains was decreased. The type (K) was found in a young girl with patient improved considerably with the recurrent respiratory infections and regular administration of 7-globulin. It diarrhea. She had, in addition, deis possible that biological as well as creased yA and yE ...
متن کاملRestricted kappa chain expression in early ontogeny: biased utilization of V kappa exons and preferential V kappa-J kappa recombinations
To determine the extent of kappa chain diversity in the preimmune repertoire early in development, kappa cDNA libraries were analyzed from 15-d old fetal omentum, 18-d-old fetal liver, and 3-wk old bone marrow. An anchored polymerase chain reaction approach was used to avoid bias for particular V kappa families. From the sequence analysis of 27 bone marrow clones, 10 different families and 20 u...
متن کاملDevelopment and characterization of polyclonal antibody against human kappa light chain in rabbit
Polyclonal antibodies against kappa light chain are used to diagnose diseases producing free light chain. The kappa and lambda light chains are products of immunoglobulin synthesis and released into the circulation in minor amounts such as serum, cerebrospinal fluid, urine and synovial fluid in normal condition. The purpose of this study was the production and purification of polyclonal immunog...
متن کاملImmunoglobulin kappa chain receptor editing in systemic lupus erythematosus.
To determine whether receptor editing of Vkappa genes was involved in the pathogenesis of systemic lupus erythematosus (SLE), the usage of Vkappa and Jkappa gene elements from individual peripheral CD19(+) B cells obtained from a patient with untreated SLE was examined. No differences in the Vkappa and Jkappa gene usage in the nonproductive gene repertoire of this SLE patient were noted compare...
متن کاملEvolution of immunoglobulin kappa chain variable region genes in vertebrates.
The major source of immunoglobulin diversity is variation in DNA sequence among multiple copies of variable region (V) genes of the heavy- and light-chain multigene families. In order to clarify the evolutionary pattern of the multigene family of immunoglobulin light kappa chain V region (V kappa) genes, phylogenetic analyses of V kappa genes from humans and other vertebrate species were conduc...
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ژورنال
عنوان ژورنال: Blood
سال: 1972
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v40.6.795.795